Plants annual. Culms 30-100 cm; nodes pubescent, hairs appressed. Sheaths with ciliate margins; ligules ciliate; blades to 12(25) cm long, to 10(20) mm wide, flat, hispid on both surfaces. Panicles 3-18 cm, loosely spicate, interrupted, often purple; rachises hispid; bristles 1-3, 5-15 mm, flexible, antrorsely scabrous. Spikelets 1.5-2.2 mm. Lower glumes about 1/3 as long as the spikelets, distinctly 3-veined, lateral veins coalescing with the central veins below the apices; upper glumes nearly equaling the upper lemmas, obtuse, 5-veined; lower lemmas equaling the upper lemmas; lower paleas about 1/3 as long as the lower lemmas, narrow; upper lemmas finely and transversely rugose; upper paleas similar to the upper lemmas. 2n = unknown.
Setaria grisebachii is the most widespread and abundant native annual species of Setaria in the southwestern United States. It grows in open ground and extends along the central highlands of Mexico to Guatemala, usually at elevations of 750-2500 m. The specimens from Maryland were collected on chrome ore piles; the species is not established in the state.