This study was carried in Siran Valley district Mansehra. (Pakistan). The method adopted for documentation of indigenous knowledge was based on questionnaire consisting of semi-structured interviews employing a checklist of questions and direct observations. The aim of the study was to collect indigenous knowledge of local inhabitants about the use of native plants, which were being utilized by the people for the treatment of different diseases. The ethnomedicinal uses of 80 plant species belonging to 49 families were recorded during field trips from the research area. The cultivated medicinal plants consists of 21 species. The check list and ethnomedicinal inventory was developed alphabetically by botanical name, followed by local name, family, part used and ethnomedicinal uses. Plant specimens were collected, identified, preserved, mounted and voucher was deposited in the Department of Plant Sciences, Quaid-I-Azam University, Islamabad for future references.